Evolutionary Reprograming of Protein-Protein Interaction Specificity
نویسندگان
چکیده
منابع مشابه
Evolutionary Reprograming of Protein-Protein Interaction Specificity
Using mutation libraries and deep sequencing, Aakre et al. study the evolution of protein-protein interactions using a toxin-antitoxin model. The results indicate probable trajectories via "intermediate" proteins that are promiscuous, thus avoiding transitions via non-interactions. These results extend observations about other biological interactions and enzyme evolution, suggesting broadly gen...
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ژورنال
عنوان ژورنال: Cell
سال: 2015
ISSN: 0092-8674
DOI: 10.1016/j.cell.2015.10.010